Order an effective treatment for hypertension
Lisinopril is a long-acting angiotensin-converting enzyme (ACE) inhibitor intended for the treatment of hypertension and the prevention of its complications. Lisinopril belongs to the II generation of ACE inhibitors. Despite the fact that the third generation of ACE inhibitors has recently appeared, lisinopril under various trade names is still widely used in clinical practice.
One of the key features of this drug is that it is not metabolized in adipose tissue, which allows it to be effectively used in overweight patients.
How does Lisinopril work?
Lisinopril, an ACE inhibitor, is used to treat and prevent heart disease (usually in doses that do not lower blood pressure) and kidney failure, as well as to lower blood pressure.
The mechanism of action of lisinopril is based on a decrease in the formation of angiotensin II and angiotensin I. Lisinopril reduces the degradation of bradykinin and increases the synthesis of prostaglandins. It reduces the total peripheral vascular resistance, blood pressure, preload, pressure in the pulmonary capillaries, causes an increase in the minute volume of blood circulation and an increase in myocardial tolerance to stress in patients with chronic heart failure.
With prolonged use, the hypertrophy of the myocardium and the walls of the resistive arteries decreases. It improves blood supply to the ischemic myocardium. ACE inhibitors prolong life expectancy in patients with CHF, slow down the progression of left ventricular dysfunction in patients who have had myocardial infarction without clinical manifestations of heart failure.
How to use Lisinopril?
Lisinopril is available in the form of pills of various dosages for oral administration. The standard regimen for taking the drug is one pill per day in the morning, regardless of the meal. It is preferable to take lisinopril every day at the same time.
The initial dose of lisinopril is 10 mg/day, the maximum dose is 40 mg/day. It may take 2-4 weeks for the full development of the effect; it should be taken into account when increasing the dose. If the use of the drug at the maximum dose does not cause a sufficient therapeutic effect, then an additional appointment of another antihypertensive drug is possible.
Before buying Lisinopril in our pharmacy, you should consult with your doctor in order to establish a specific treatment regimen.
What contraindications Lisinopril has?
Taking Lisinopril is contraindicated in patients with a history of angioedema, including from the use of ACE inhibitors, with hereditary angioedema, patients under 18 years of age and those who have hypersensitivity to lisinopril or other ACE inhibitors.
The most common side effects: dizziness, headache (in 5-6% of patients), weakness, diarrhea, dry cough (3%), nausea, vomiting, orthostatic hypotension, skin rash, chest pain (1-3%).
A complete list of contraindications and possible side effects can be found in the official instructions accompanying lisinopril when ordering from our pharmacy.
